It’s Here: Fact or Fiction

Many sources tell us that approximately 2 million people per year are affected by a traumatic brain injury (TBI). Recovery after a TBI is typically a lengthy process, but now, as reported by Denise Dador of KABC-TV/DT in Los Angeles, clinical trials are taking place to determine whether or not a proposed treatment may shorten the recovery process by reducing brain swelling.

Lester Talley CrashIn the article, Dador interviews Lester Talley after Talley lost consciousness and drove his car into the back of a parked 18 wheeler. While Talley was in a coma, his wife enrolled him in a “phase three clinical trial called SyNAPSe, short for Study of the Neuroprotective Activity of Progesterone in Severe Traumatic Brain Injuries.”


Dador quoted Dr. Daniel Laskowitz, professor in neurology at Duke University as saying “the research is testing if progesterone could help treat TBI. [Progesterone] is a natural hormone produced in men and women that’s most often associated with pregnancy. There is good evidence that it reduces inflammation.”

According to Dador, “more than 150 sites in 21 countries are taking part in the SyNAPSe trial. The goal is to enroll more than 1,100 TBI patients. A 2012 review of the first 200 study participants found there were no safety concerns associated with the treatment.”


  • What, if anything, concerns you about the study?
  • What, if anything, excites you about the study?
  • What do you think would make a difference in your recovery?

Thanks to Wendy for sharing the article with me, KABC-TV/DT for posting the story, Denise Dador for conducting the interview, Lester Talley for sharing his story,  Dr. Daniel Laskowitz  a professor in neurology for explaining the SyNAPSe study, Duke University for allowing the study, and BHR Pharma for designing, financing, and managing the SyNAPSe  study.

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